The Standards for obvious reasons: Photoshop, ImageReady, Illustrator, Corel Draw - for web design --- i prefer Corel over Illustrator (though version 8 has many long awaited improvements --- that Corel has had since 1992).

After Effects, Premier, Avid Video Shop and MCXpress - for video editing and motion graphics.

Quark - for print (and sometimes interactive --- i'm more comfortable using type in Quark and converting to EPS).

Director, Flash - for interactive.

plus various HTML editors: BBEdit, HomeSite, etc.

work on both Macintosh and PC - it's a love/hate relationship with both.